- Roy Aitken – Irvine-born footballer who made over 600 appearances for Celtic.
- Andrew Auld – Stevenston-born footballer who played in the 1930 World Cup for the USA.
- Jim Brown – Kilmarnock-born footballer who played for the USA national team at the 1930 FIFA World Cup.
- George Burley – Cumnock-born footballer and manager, who played for and managed the Scottish national team.
- Steve Clarke – Saltcoats-born football player and manager.
- Thomas Clifford – Kilbirnie-born footballer who played for multiple teams (including Celtic and Motherwell) who was killed in France during WWI in 1917.
- Duncan Currie – Kilwinning-born footballer who made 45 appearances for Hearts who was killed in France during WWI.
- Jimmy Galt – Footballer from Saltcoats who went on to play for Rangers. Fought in WWI and survived the war.
- Jimmy Gordon – Saltcoats-born footballer who made 388 appearances for Rangers.
- George Hamilton – Footballer from Irvine who part of the 1954 FIFA World Cup squad for Scotland.
- Bobby Lennox – Legendary Scottish footballer who played for Celtic and Scotland.
- Lou Macari – Legendary former Celtic & Manchester United player.
- Alan McInally – Footballer from Ayr who was part of the 1990 FIFA World Cup squad for Scotland.
- Gordon McQueen – Footballer who played for St Mirren, Leeds & Manchester United. Inducted into the Scottish Football Hall of Fame in 2012.
- Charles William Miller – Brazilian-born son of John Miller (who was born in Fairlie), who introduced football to Brazil.
- Steve Nicol – Footballer from Troon who was part of the 1986 FIFA World Cup Scotland squad.
- Alex Parker – Footballer from Irvine who played for Scotland at the 1958 FIFA World Cup.
- Jemma Reekie – Olympic runner from Beith who has won gold at the U-20 & U-22 European Championships.
- Jim Stewart – Footballer from Kilwinning who was part of Scotland’s 1974 FIFA World Cup squad.
- William Wilton – Largs-born footballer who would become the first manager of Rangers and achieved a 100% league record and won multiple trophies.